Bacopa Targets Joint Inflammation

KERALA, IndiaThe Ayurvedic herb Bacopa monniera has antiarthritic effects rooted in anti-inflammatory actions, according to a recent study from University of Kerala researchers. Published online ahead of print in Phytotherapy Research, the investigation focused on the therapeutic efficacy of bacopa extract in treating rheumatoid arthritis in rats.

Researchers administered bacopa extract to rats for a total of 60 days; they looked at paw swelling, arthritic index, inflammatory mediators such as cyclooxygenase (COX), lipoxygenase (LOX), myeloperoxidase and serum anti-collagen IgG and IgM levels in control and experimental rats. Results revealed significantly inhibited the footpad swelling and arthritic symptoms in bacopa-treated animals. Bacopa also inhibited cyclooxygenase and lipoxygenase activities, in addition to reducing neutrophil infiltration and  serum anti-collagen IgM and IgG levels in the arthritic rats. The researchers concluded Bacopa monniera extract has antirheumatic activities that demonstrate the herb has potential antiarthritic applications.