Peptan Benefits Bone Health

PARISDietary hydrolyzed collagen (as Peptan) increases osteoblast activity, which acts on bone remodeling and increases the external diameter of cortical areas of the femurs, according to a recent study in Bone journal (2009; DOI:10.1016/j.bone.2009.10.035). An in vivo study was carried out in 12-week-old female C3H/HeN mice, either ovariectomized (OVX) or sham-operated (SHAM) and fed for 12 weeks with a diet containing 10 or 25 g/kg of hydrolyzed collagen.

The bone mineral density (BMD) for OVX mice fed the diet including 25 g/kg of hydrolyzed collagen was significantly higher as compared to OVX mice. The blood C-terminal telopeptide of type I collagen (CTX) level significantly decreased when mice were fed with either of the diets containing hydrolyzed collagen. There was a significant increase in bone strength correlated to geometrical changes for the OVX mice fed the 25 g/kg hydrolyzed collagen diet. Hydrolyzed collagens in the tissue culture medium did not have any significant effects on cell growth as compared to controls. However, there was a significant and dose-dependent increase in alkaline phosphatase (ALP) activity, a well-known marker of osteogenesis, and a decrease in octeoclast activity in primary culture of bone cells cultured with hydrolyzed collagens as compared to the control.