DSMs Fabuless® Ups Satiety by Resisting Absorption

PARSIPPANY, N.J.DSM Nutritional Products weight-management ingredient Fabuless® exerts its appetite-reducing effects by resisting absorption, leading to almost double the amount of lipids progressing from the upper gastrointestinal tract to the small intestine, according to a new study from the Uppsala University, Sweden, and DSM Food Specialties BV, Delft, Netherlands (Am J Clin Nutr. June 23, 2010. doi:10.3945/ajcn.2009.28941).

The controlled, double-blind, cross-over-designed study compared Fabuless, which combines oat and palm oils, and a control milk fat in 16 subjects with healthy weight. Researchers gave subjects either a test product (yogurt with Fabuless) or an equal-calorie milk fat control by intragastric administration on two separate occasions. Gastric and intestinal samples were collected from the upper gastrointestinal tract after three hours.

Total lipids, mainly as free fatty acids, were almost doubled (P<0.05)  in the Fabuless group (450 ± 119 mg) in the upper gastrointestinal tract compared with amounts of total lipids from the milk fat product (230 ± 50 mg), and an over-time difference of free fatty acid concentrations was observed between the products (P<0.05).  This showed compared to a milk fat, the fat derived from Fabuless was found to resist absorption.

Additionally, fatty acid-containing crystals were observed in abundance in the Fabuless group. The higher amount of lipids in the middle section of the small intestine and the presence of fatty acid crystals offer coherent evidence for enhanced appetite control through the ileal brake mechanism. Fabuless enhanced the "appetite satisfied" message from the gut system to the brain as part of the bodys normal regulatory mechanism related to energy intake.

We are very pleased with these results as they provide an in-depth understanding of the mechanism behind the appetite-reducing effect of Fabuless, commented Philip Rijken, head of Nutritional Science Europe and Asia Pacific at DSM Nutritional Products. The new evidence further validates the enhanced appetite control response to Fabuless by detailing its physiological basis.  The data add to a previous mechanism of action study, showing that Fabuless induces a significant delay in food-transit time. We expect that these latest insights into the mechanism of action will be received with a lot of interest by the scientific community.

DSMs proprietary Fabuless Fabuless can be consumed on its own or as the key ingredient in a variety of applications including milk, yogurt, meal-replacer drinks, and supplement sachets and stick packets.