Omega-3s May Prevent Fatty Liver Disease

CORVALLIS, Ore.Omega-3 fatty acids may have a significant impact in the prevention of fatty liver disease, according to a study appearing in PLOS ONE.

This was the first study type to use metabolomics, an analysis of metabolites that reflect the many biological effects of omega-3 fatty acids on the liver. It also explored the challenges the liver faces from the typical Western diet.

We were shocked to find so many biological pathways being affected by omega-3 fatty acids," said Donald Jump, professor in the Oregon State University College of Public Health and Human Sciences. Most studies on these nutrients find effects on lipid metabolism and inflammation. Our metabolomics analysis indicates that the effects of omega-3 fatty acids extend beyond that, and include carbohydrate, amino acid and vitamin metabolism."

Supplementation with DHA partially or totally prevented metabolic damage through those pathways often linked to the Western diet which includes excessive consumption of red meat, sugar, saturated fat and processed grains.

 A lot of work has been done on fatty liver disease, and we are just beginning to explore the potential for DHA in preventing or slowing disease progression," said Jump.