Study: MemreePlus Decreases Stress Response in Men

BASEL, Switzerland—A study confirms that Lonza’s MemreePlus blend of soy-based phosphatidylserine (PS) phosphatdic acid (PA), can decrease the stress response in chronically stressed male adults. (Lipids in Health and Disease. 2014 July;13(121))

Chronic mental stress can lead to adverse physiological and psychological outcomes. Physiological outcomes are typically related to a dysregulation of the stress hormone cortisol. In acutely stressful situations, cortisol helps increase glucose availability, blood pressure and mental performance. Over time, chronically high levels of cortisol can lead to impaired glucose tolerance, increased weight gain, decreased immune response and memory impairment.

For the study, 75 male adults were divided by chronic stress level and randomly assigned to one of three study groups. After six weeks of supplementing with MemreePlus, the participants completed the Trier Social Stress Test (TSST), a combination of a job interview style presentation followed by a math challenge designed to provoke a certain stress response. The study was randomized, double-blind and placebo controlled.

Stress biomarkers were assessed before and at certain time intervals after the TSST. Compared to the placebo group, the MemreePlus group was effective in normalizing adrenocorticotropic hormone, salivary, and serum cortisol responses to the TSST in chronically high-, but not in low-stressed subjects.

Lonza launched its soy-based MemreePlus in 2012.