Gut Microbes Affect Severity of Melamine-Induced Renal Disease

LONDONMicrobes present in the digestive tract can affect the severity of kidney disease brought on by melamine poisoning, according to a new study published in the journal Science Translational Medicine. The findings suggest certain species of gut microbes are responsible for converting melamine into the toxic cyanuric acid, thereby accelerating the rate at which kidney stones are formed.

In 2008, nearly 300,000 Chinese children were hospitalized with kidney disease brought on by supplies of powdered milk deliberately contaminated with melamine to boost the apparent protein content. Although melamine was known to combine with uric acid in the childrens bodies to produce harmful kidney stones, the details of the reaction and the role of specific gut microbes were not well understood.

Researchers at the University of North Carolina and Imperial College London investigated how melamine contributes to the development of kidney stones in rats and showed experimentally that gut microbes may be central to understanding melamine-induced kidney failure in humans. Tests on rats showed that the presence of microbes of the Klebsiella family tended to facilitate the process of melamine conversion, potentially making them key players in the formation of kidney stones. This study suggests that toxicity in this case is linked to the make-up of gut microbes in the poisoned organism.

The metabolic activities of gut microbes strongly  influence human health in profound ways and have been linked to the development of multiple medical problems ranging from autoimmune diseases, obesity, diabetes, and cardiovascular disease," the researchers said. The specific implication of this research is that the expression of the kidney disease in the Chinese contaminated milk scandal is likely to have been mediated by gut bacteria in affected children. The more general implication is that gut microbial status affects the outcome to exposures to environmental and food contaminants."