Tocomin SupraBio® Improves Liver Stiffness

EDISON, N.J.At the recently concluded Asian Pacific Association for the Study of the Liver (APASL), a research team of medical doctors from the Philippines, led by Marilyn Arguillas, M.D., PFCP, FPSG, FPSDE, showed supplementation with Tocomin SupraBio®, a full-spectrum palm tocotrienol/tocopherol complex (manufactured by Carotech), at 100 mg/d for three months significantly reduces liver stiffness in patients with non-alcoholic fatty liver disease (NAFLD).

Arguillas used non-invasive transient elastography (FibroScan) to measure liver stiffness among NAFLD patients. The development of fibrosis marks the connection between fatty liver disease and end-stage liver disease," Arguillas said in a newspaper interview.

The study involved 67 patients for three months. Patients were divided into two groups (treatment group and control group). Both groups were placed under lifestyle modification advice group (LMAG), which included nutritional counseling and advice on exercise. The treatment group, however, was also placed on 100 mg/d of mixed tocotrienol (containing Tocomin SupraBio).

After three months, 57 percent of all patients (n=38) showed a decrease in their liver stiffness measurement, but 43 percent (n=29) did not improve. Seventy-nine percent of those who improved were from the treatment group and 21 percent from LMAG alone. Out of the 29 patients who did not improve, 23 patients or 79 percent are from LMAG alone and only six patients or 21 percent from treatment group. The study shows that lifestyle modification and exercise together with supplementation of tocotrienol had a significant effect on the improvement of liver stiffness.

In an earlier animal study, Japanese researchers reported simultaneous intake of tocotrienols with alpha-tocopherol synergistically inhibited lipid accumulation, inflammation and fibrosis in the liver, which further underscores the importance of tocotrienols and tocopherols in reducing the severity or risk of NAFLD.

Human studies using Tocomin SupraBio have previously shown that tocotrienols improve liver conditions in NAFLD and end stage liver disease and that alpha-tocopherol works in a synergistic manner with tocotrienols in exerting these liver protective effects," said WH Leong, Vice President of Carotech Inc. "We are pleased to learn of this latest study from the Philippines, which further supports hepatoprotective benefits of Tocomin SupraBio.

Source: The Effect of Vitamin E (Mixed Tocotrienol) on the Liver Stiffness measurement Measured by Transient Elastography (FibroScan) among NAFLD Patients", presented at APASL Liver Week, Singapore, June 7, 2013.