Study Finds Super CitriMax® Up-regulates Genes

Study Finds Super CitriMax® Up-regulates Genes

BENICIA, Calif.A new studyfound InterHealth Nutraceuticals (www.InterHealthUSA.com) Super CitriMax®increases the activity of genes involved with carbohydrate and fat metabolism,as well as appetite control. Super CitriMax is derived from the South Asianfruit Garcinia cambogia,which is sold as a weight loss ingredient.

The study, conducted by researchers at Ohio State UniversityMedical Center, Columbus, and published in GeneExpression (11:251- 62, 2004), found Super CitriMaxup-regulated more than 90 genes, while it had no affect on genes considered tobe indicators of toxicity in the body. More significantly, Super CitriMaxup-regulated an entire family of genes involved in the signaling activity ofserotonin, a brain chemical that affects sleep patterns, moods and appetite.

We have long-known that serotonin may play a role inappetite suppression, but these study results provide preliminary evidence thatserotonin may be regulated by dietary supplements, said Chandan Sen, Ph.D.,the studys lead researcher.

The new study corroborates earlier studies in animals and,more recently, in humans showing that Super CitriMax increases serotonin levels,reduces appetite and decreases body weight. Recent studies also show SuperCitriMax also helps maintain healthy cholesterol levels (NutritionResearch (24:45-58, 2004) and Diabetes,Obesity and Metabolism (6:171- 180, 2004)). Harry G.Preuss, M.D., lead researcher on the human clinicals, said, "While we havebelieved for some time that HCA held significant promise in the treatment ofobesity, this study, utilizing effective doses of bioavailable hydroxycitrate,marks the first time that such a comprehensive, wellmonitored clinical study hasdefinitively confirmed its effectiveness and safety in human subjects.