Ai/E10® Increases Immune Gene Response

MILAN, ItalyMice that received Ai/E¹⁰® (a bovine-derived dietary ingredient from Health Technology Resources Inc., Scottsdale, AZ) had more up-regulation of genes associated with innate and adaptive immunity than mice that did not receive the supplement, according to a new study (Nutr Dietary Supp. 2011 Sept;2011(3) 8992. DOI: 10.2147/NDS.S23701).

The double blind, ex vivo mouse study fed BALB/c female mice (5 to 6 weeks of age) chewy granola bars supplemented with or without  Ai/E¹⁰ for 10 days. After the feeding period, the animals were sacrificed and spleen cells were isolated and incubated with lipopolysaccharide and phorbol myristate acetate-ionomycin, both of which stimulate an immune response.

The researchers reported numerous genes associated with innate and adaptive immunity were up-regulated in the Ai/E¹⁰ group when stimulated with mitogens, which triggers cell division. Significant up-regulation was observed in 30 percent (25 of 84) of genes upon lipopolysaccharide stimulation and in 14 percent (12 of 84) of genes upon phorbol myristate acetate  ionomycin stimulation in the Ai/E10group relative to controls.

In addition, the study showed the benefit afforded by Ai/E¹⁰ was modulatory and not stimulatory.

This study complements a trial published late last year that showed Ai/E10 supported natural killer (NK) cell activity in healthy humans and contributed to an overall improvement in health and well-being.

Dietary Ingredient Solutions, LLC (DIS) introduced the dietary ingredient Ai/E10 for the support of human immunity in 1994. Ai/E¹⁰ is distributed worldwide. Health Technology Resources Inc. will be available to discuss this study at the Stauber Booth #14029 at SupplySide West.