Capsaicin May Treat Brain Tumors

SUWON, KoreaCapsaicin, a pungent ingredient of red chili peppers, and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) may provide a safe and effective strategy for treating malignant gliomas, according to study published in Carcinogenesis (2010;31(3):367-75). Research shows subtoxic doses of capsaicin effectively sensitize multiple malignant glioma cell lines to TRAIL-induced apoptosis. Although TRAIL alone mediated partial proteolytic processing of procaspase-3 in glioma cells, co-treatment with capsaicin and TRAIL efficiently restored complete activation of caspases. Researchers found treatment of various gliomas with capsaicin significantly upregulated DR5, a death receptor of TRAIL, and downregulated the caspase inhibitor survivin. The induction of DR5 was mediated by CHOP/GADD153. The reduction in survivin protein level was associated with downregulation of cyclin B and Cdc2 expression, suggesting inhibition of Cdc2 activity might contribute to capsaicin-induced survivin downregulation. Taken together, these results indicate the activity of capsaicin toward DR5 and survivin contributes to the amplification of caspase cascades, thereby restoring TRAIL sensitivity in malignant glioma cells. Interestingly, normal astrocytes were resistant to combined treatment with capsaicin and TRAIL. Neither capsaicin-induced DR5 upregulation/survivin downregulation nor the partial processing of procaspase-3 by TRAIL was induced in astrocytes.