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DHA Signal Lipidomics
July 25, 2011
1 Min Read
NEW ORLEANSDocosahexaenoic acid (DHA) is readily taken up and concentrated in the nervous system, particularly in photoreceptors and synaptic membranes, andplays a key role in vision, neuroprotection, aging, memory and other functions. A recent review published in Annual Reviews Nutrition (2011 Aug 21;31:321-51) looked at the signal lipidomics of DHA, including:
the cellular/tissue organization of DHA uptake,
DHA distribution among cellular compartments,
the organization and function of membrane domains rich in DHA-containing phospholipids, and
the cellular and molecular events revealed by the uncovering of signaling pathways regulated by DHA and docosanoidsDHA-derived bioactive lipids such as neuroprotectin D1 (NPD1), a novel DHA-derived stereoselective mediator.
Researchers, from Louisiana State University Health Sciences Center, noted the DHA-derived NPD1 triggers potent anti-inflammatory actions and pro-homeostatic bioactivity, is anti-angiogenic, promotes corneal nerve regeneration, and induces cell survival.
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