Flavanoids References

March 28, 2005 - Natural Products Industry INSIDER
"Flavonoids" References

1. Nuttall SL et al. An evaluation of the antioxidant activity of astandardized grape seed extract, Leucoselect.. J Clin Pharm Ther.23(5):385-9, 1998.

2. Richelle M et al. Plasma kinetics in man of epicatechin from blackchocolate. Eur J Clin Nutr 53(1):22-26, 1999.

3. Aviram M et al. "Pomegranate juice flavonoids inhibit low-densitylipoprotein oxidation and cardiovascular diseases: studies in atheroscleroticmice and in humans." Drugs Exp Clin Res. 28, 2-3:49-62, 2002.

4. Manthey JA, Guthrie J. Antiproliferative activities of citrusflavonoids against six human cancer cell lines. J Agric Food Chem.50(21):5837-43, 2002.

5. Henning M et al. Bioavailability and antioxidant activity of teaflavanols after consumption of green tea, black tea, or a green tea extractsupplement. Am J Clin Nutr. 80, 6:1558-64, 2004.

6. Yasmin T et al. "Antioxidant capacity and safety of variousanthocyanin berry extract formulaions." Res Commun Pharmacol Toxicol.8:25-36, 2003.

7. Abuja P et al. Antioxidant and Prooxidant Activities of Elderberry (Sambucusnigra) in Low-Density Lipoprotein Oxidation. J of Ag Food Chem46:4091-96, 1998.

8. Dreosti IE et al. "Inhibition of carcinogenesis by tea: the evidencefrom experimental studies." Crit Rev Food Sci Nutr. 37, 8:761-70,1997. www.sciencedirect.com/science/journal/10408398

9. Williamson G, Crespy V. A review of the health effects of green teacatechins in in vivo animal models. J Nutr. 134(12):3431S-3440S, 2004.

10. Gupta S et al. Oral consumption of green tea polyphenols inhibitsinsulin-like growth factor-I-induced signaling in an autochthonous mouse modelof prostate cancer. Cancer Res. 64(23):8715-22, 2004.

11. Dufresne CJ, Farnworth ER. A review of latest research findings on thehealth promotion properties of tea. J Nutr Biochem.12(7):404-421,2001.

12. Sengupta A et al. Tea can protect against aberrant crypt fociformation during azoxymethane induced rat colon carcinogenesis. J Exp ClinCancer Res. 22(2):185-91, 2003.

13. Mukamal KJ et al. "Alcohol consumption and hemostatic factors:Analysis of the Framingham Offspring Cohort." Circulation. 104:1367-73, 2001. http://circ.ahajournals.org

14. Negishi H et al. "Black and green tea polyphenols attenuate bloodpressure increases in stroke-prone spontaneously hypertensive rats." JNutr. 134(1):38-42, 2004. www.nutrition.org

15. Shoskes D et al. "Quercetin in men with category III chronicprostatitis: a preliminary prospective, double blind, placebo-controlledtrial." Urology. 54, 6:960-963, 1999. http://www.goldjournal.net/

16. Hamilton-Miller JM. "Anti-cariogenic properties of tea (Camelliasinensis)." J Med Microbiol. 50, 4:299-302, 2001. www.urbanfischer.de/journals/ijmm/bakteriol.htm

17. Kawai, K et al. "Epigallocatechin gallate, the main component of teapolyphenol, binds to CD4 and interferes with gp120 binding." J AllergyClin Immunol. 112, 5:951-7, 2003. http://www2.us.elsevierhealth.com/scripts/
om.dll/serve?action=searchDB&searchDBfor=home&id=ai

18. Li R et al. (-)-Epigallocatechin gallate inhibitslipopolysaccharide-induced microglial activation and protects againstinflammation-mediated dopaminergic neuronal injury.J Neurosci Res.78(5):723-31, 2004.

19. Mandel S et al. "Cell signaling pathways in the neuroprotectiveactions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implicationsfor neurodegenerative diseases." J Neurochem. 88, 6:1555-69, 2004.

20. Choi YT et al. The green tea polyphenol (-)-epigallocatechin gallateattenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons.Life Sci. 70(5):603-14, 2001.

21. Alessio HM et al Consumption of green tea protects rats fromexercise-induced oxidative stress in kidney and liver Nutr Res. 22,10:1177-88, 2002. www.elsevier.com/locate/issn/02715317

22. Fiorini RN et al. Short-term administration of (-)-epigallocatechingallate reduces hepatic steatosis and protects against warm hepaticischemia/reperfusion injury in steatotic mice.  Liver Transpl.11(3):298-308, 2005.

23. Tsuneki H et al. Effect of green tea on blood glucose levels and serumproteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthyhumans. BMC Pharmacol. 4(1):18, 2004.

24. Nagao T et al. Ingestion of a tea rich in catechins leads to areduction in body fat and malondialdehyde-modified LDL in men Amer J ClinNutr. 81, 1:122-129, 2005. www.ajcn.org

25. Kundu JK, Surh YJ. Molecular basis of chemoprevention by resveratrol:NF-kappaB and AP-1 as potential targets. Mutat Res. 555(1-2):65-80,2004.

26. Banerjee et al. Suppression of 7,12-dimethylbenz(a)anthracene-inducedmammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB,cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res.62(17):4945-54, 2002. www.cancerres.aacrjournals.org

27. Aziz MH et al. Cancer chemoprevention by resveratrol: in vitro and invivo studies and the underlying mechanisms (review). Int J Oncol.23(1):17-28, 2003.

28. Le Corre L et al. Resveratrol and breast cancer chemoprevention:Molecular mechanisms. Mol Nutr Food Res. [Epub ahead of print] Mar 22,2005. http://www3.interscience.wiley.com/
cgi-bin/abstract/110432503/ABSTRACT

29. Nomoto H et al. Chemoprevention of colorectal cancer by grape seedproanthocyanidin is accompanied by a decrease in proliferation and increase inapoptosis. Nutr Cancer. 49(1):81-8, 2004.

30. Ye X et al. "The cytotoxic effects of a novel IH636 grape seedproanthocyanidin extract on cultured human cancer cells." Mol CellBiochem. 196, 1-2:99-108, 1999. www.wkap.nl

31. Bagchi D, Sen CK. Regulation of inducible adhesion molecule expressionin human endothelial cells by grape seed proanthocyanidin extract. MolCell Biochem. 216(1-2):1-7, 2001.

32. Bagchi D et al. Protective effects of grape seed proanthocyanidins andselected antioxidants against TPA-induced hepatic and brain lipid peroxidationand DNA fragmentation, and peritoneal macrophage activation in mice.GenPharmacol. 30(5):771-6, 1998.

33. Vigna GB et al. Effect of a standardized grape seed extract onlow-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism.52(10):1250-7, 2003.

34. Auger C et al. Phenolics from commercialized grape extracts preventearly atherosclerotic lesions in hamsters by mechanisms other than antioxidanteffect. J Agric Food Chem. 52(16):5297-302, 2004.

35. Tyson DA et al. "Acute effects of grape seed extract andniacin-bound chromium on cardiovascular parameters of normotensive andhypertensive rats." Res Comm Pharmacol Toxicol. 5, 1-2:91-106, 2000.

36. Nair MP et al. Grape seed extract proanthocyanidins downregulate HIV-1entry coreceptors, CCR2b, CCR3 and CCR5 gene expression by normal peripheralblood mononuclear cells. Biol Res. 35(3-4):421-31, 2002.

37. Deshane J et al. Proteomics analysis of rat brain protein modulationsby grape seed extract. J Agri Food Chem. 52(26):7872-7883, 2004. http://pubs.acs.org/journals/jafcau/index.html

38. Preuss HG et al. "Protective effects of a novel niacin-boundchromium complex and a grape seed proanthocyanidin extract on advancing age andvarious aspects of syndrome X." Ann N Y Acad Sci. 957:250-9, 2002.

39. Watson R. Reduction of cardiovascular disease risk factors by Frenchmaritime pine bark extract. Cardiovasc Rev Report. 6:326-329, 1999.

40. Huynh HT, Teel RW. Selective induction of apoptosis in human mammarycancer cells (MCF-7) by pycnogenol. Anticancer Res. 20(4):2417-20,2000.

41. Liu X et al. Antidiabetic effect of Pycnogenol French maritime pinebark extract in patients with diabetes type II. Life Sci.75(21):2505-13, 2004.

42. Liu X et al. Pycnogenol, French maritime pine bark extract, improvesendothelial function of hypertensive patients. Life Sci. 74(7):855-62,2004.

43. Peng QL et al. Pycnogenol protects neurons from amyloid-betapeptide-induced apoptosis. Brain Res Mol Brain Res. 104(1):55-65,2002.

44. Stefanescu M et al. Pycnogenol efficacy in the treatment of systemiclupus erythematosus patients. Phytother Res. 15(8):698-704, 2001.

45. Spadea L, Balestrazzi E. Treatment of vascular retinopathies withPycnogenol. Phytother Res. 15(3):219-23, 2001.

46. Lau BH et al. Pycnogenol as an adjunct in the management of childhoodasthma. J Asthma. 41(8):825-32, 2004.

47. Sharma SC et al. Pycnogenol inhibits release of histamine from mastcells. Phytother Res. 17(1):66-9, 2003.

48. Belcaro G et al. Prevention of venous thrombosis and thrombophlebitisin long-haul flights with pycnogenol. Clin Appl Thromb Hemost.10(4):373-7, 2004.

49. Kohama T et al. Analgesic efficacy of French maritime pine barkextract in dysmenorrhea: an open clinical trial. J Reprod Med.49(10):828-32, 2004.

50. Liu FJ et al. Pycnogenol enhances immune and haemopoietic functions insenescence-accelerated mice. Cell Mol Life Sci. 54(10):1168-72, 1998.

51. Roseff SJ. Improvement in sperm quality and function with Frenchmaritime pine tree bark extract. J Reprod Med. 47(10):821-4, 2002.

52. Roseff SJ et al. Oral administration of Pycnogenol affects baselinehuman sperm morphology, but not sperm count, motility or functions. FertilSteril. 70(3):S265-66, 1998.

53. Heimann SW. Pycnogenol for ADHD? J Am Acad Child AdolescPsychiatry. 38(4):357-358, 1999.

54. Pavlovic P. Improved endurance by use of antioxidants. Euro BullDrug Res. 7(2):26-9, 1999.

55. Sweeney MI et al. Feeding rats diets enriched in lowbush blueberriesfor six weeks decreases ischemia-induced brain damage. Nutr Neurosci.5(6):427-31, 2002.

56. Joseph JA et al. Long-term dietary strawberry, spinach, or vitamin Esupplementation retards the onset of age-related neuronal signal-transductionand cognitive behavioral deficits. J Neurosci. 18, 19:8047-55, 1998. http://www.jneurosci.org

57. Meyers KJ et al. Antioxidant and antiproliferative activities ofstrawberries. J Agric Food Chem. 51(23):6887-92, 2003.

58. Casto BC et al. Chemoprevention of oral cancer by black raspberries. AnticancerRes. 22, 6C:4005-15, 2002. http://www.iiar-anticancer.org/index2.htm

59. Harris GK et al. Effects of lyophilized black raspberries onazoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in theFischer 344 rat. Nutr Cancer.40, 2:125-33, 2001. http://www.leaonline.com/loi/nc

60. Sun J et al. Antioxidant and antiproliferative activities of commonfruits. J Agric Food Chem. 50, 25:7449-54, 2002. http://pubs.acs.org/journals/jafcau

61. McHarg T et al. Influence of cranberry juice on the urinary risk factorsfor calcium oxalate kidney stone formation. BJU Int. 92, 7:765-8, 2003. http://www.bjui.org

62. Yamanaka A et al. Inhibitory effects of cranberry juice on attachment oforal streptococci and biofilm formation. Oral Microbiol Immunol. 19,3:150-4, 2004. (http://www.blackwellpublishing.com/journal.asp?ref=0902-0055)

63. McHarg T et al. Influence of cranberry juice on the urinary risk factorsfor calcium oxalate kidney stone formation. BJU Int. 92, 7:765-8, 2003. http://www.bjui.org

64. Sparrow JR et al. "A2E-epoxides damage DNA in retinal pigmentepithelial cells. J Biol Chem. 278, 20:18207-13, 2003. www.jbc.org

65. Aziz RM et al. Inhibition of cellular transformation by berryextracts. Carcinogen. 22(2):351-56, 2001.

66. Daniel RS et al. Mechanism of action of antiatherogenic and relatedeffects of Ficus bengalensis Linn. flavonoids in experimental animals. IndianJ Exp Biol. 41, 4:296-303, 2003. http://www.niscair.res.in/ScienceCommunication/
ResearchJournals/rejour/ijeb/ijeb2k3/ijeb_apr03.htm

67. Bagchi D et al. Anti-angiogenic, antioxidant, and anti-carcinogenicproperties of a novel anthocyanin-rich berry extract formula. Biochemistry(Mosc). 69(1):75-80, 2004.

68. Roy S et al. Anti-angiogenic property of edible berries. FreeRadic Res. 36(9):1023-31, 2002.

69. Chatterjee A et al. Inhibition of Helicobacter pylori in vitro byvarious berry extracts, with enhanced susceptibility to clarithromycin. MolCell Biochem. 265(1-2):19-26, 2004.

70. Mathur S et al. "Cocoa products decrease low density lipoproteinoxidative susceptibility but do not affect biomarkers of inflammation inhumans." J Nutr. 132, 12:3663-7, 2002. www.nutrition.org

71. Rein D et al. "Cocoa inhibits platelet activation andfunction." Am J Clin Nutr. 72, 1:30-5, 2000. www.ajcn.org

72. Innes AJ et al. "Dark chocolate inhibits platelet aggregation inhealthy volunteers." Platelets. 14, 5:325-7, 2003. www.tandf.co.uk/journals/titles/09537104.asp

73. Lee CH et al. "Anti-atherogenic effect of citrus flavonoids,naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 andMCP-1 in high cholesterol-fed rabbits." Biochem Biophys Res Comm.284, 3:681-8, 2001. www.sciencedirect.com/science/journal/0006291X

74. Ohtsuki K et al. Effects of long-term administration of hesperidin andglucosyl hesperidin to spontaneously hypertensive rats. J Nutr SciVitaminol (Tokyo). 48(5):420-2, 2002.

75. Barrett PH et al. Hepatocyte apoB-containing lipoprotein secretion isdecreased by the grapefruit flavonoid, naringenin, via inhibition ofMTP-mediated microsomal triglyceride accumulation. Biochemistry.42(5):1283-91, 2003.

76. Whitman SC et al. "Nobiletin, a citrus flavonoid isolated fromtangerines, selective inhibits class A scavenger receptor-mediated metabolism ofacetylated LDL by mouse macrophages." Atherosclerosis. [in press2005] www.elsevier.com/locate/atherosclerosis

77. Vinson JA et al. Polyphenol antioxidants in citrus juices: in vitroand in vivo studies relevant to heart disease. Adv Exp Med Biol.505:113-22, 2002.

78. Kurowska EM, Manthey JA. "Hypolipidemic effects and absorption ofcitrus polymethoxylated flavones in hamsters with diet-inducedhypercholesterolemia." J Agric Food Chem. 52, 10:2879-86, 2004. http://pubs.acs.org/journals/jafcau

79. Tahbaz F et al. Concentrated pomegranate juice improves lipid profilesin diabetic patients with hyperlipidemia. J Med Food. 7(3):305-8,2004.

80. Aviram M et al. Pomegranate juice flavonoids inhibit low-densitylipoprotein oxidation and cardiovascular diseases: studies in atheroscleroticmice and in humans. Drugs Exp Clin Res. 28(2-3):49-62, 2002.

81. Aviram et al. Pomegranate juice consumption for 3 years by patientswith carotid artery stenosis reduces common carotid intima-media thickness,blood pressure and LDL oxidation. Clin Nutr. 23(3):423-33, 2004.

82. Kong AN et al. Induction of xenobiotic enzymes by the MAP kinasepathway and the antioxidant or electrophile response element (ARE/EpRE). DrugMetab Rev. 33(3-4):255-271, 2001.

83. Bagli E et al. Luteolin inhibits vascular endothelial growthfactor-induced angiogenesis; inhibition of endothelial cell survival andproliferation by targeting phosphatidylinositol 3'-kinase activity. CancerRes. 64(21):7936-7946, 2004.

84. Wang W et al. Individual and interactive effects of apigenin analogson G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer.48(1):106-114, 2004.

85. Sah JF et al. Epigallocatechin-3-gallate inhibits epidermal growthfactor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 andAKT kinases. J Biol Chem. 279(13):12755-12762, 2004.

86. Kavanagh KT et al. Green tea extracts decrease carcinogen-inducedmammary tumor burden in rats and rate of breast cancer cell proliferation inculture. J Cell Biochem. 82(3):387-398, 2001.

87. Sakata K et al. Inhibition of inducible isoforms of cyclooxygenase andnitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. CancerLett. 199(2):139-145, 2003.

88. Ludwig A et al. The tea flavonoid epigallocatechin-3-gallate reducescytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells.Biochem Biophys Res Commun. 316(3):659-665, 2004.

89. Anter E et al. Activation of eNOS by the p38 MAP kinase in response toblack tea polyphenols. J Biol Chem. 279(45):46637-43, 2004.

90. Bucki R et al. Flavonoid inhibition of platelet procoagulant activityand phosphoinositide synthesis. J Thromb Haemost. 1(8):1820-1828,2003.

91. Cho SY et al. Quercetin suppresses proinflammatory cytokinesproduction through MAP kinases andNF-kappaB pathway inlipopolysaccharide-stimulated macrophage. Mol Cell Biochem.243(1-2):153-160, 2003.

92. Kester A et al. Capillary Electrophoretic Determination of Resveratrolin Wines. J Agri Food Chem. 47(8):3223-27, 1999. http://pubs.acs.org/journals/jafcau/

93. Wang Y et al. An LC-MS Method for Analyzing Total Resveratrol in GrapeJuice, Cranberry Juice, and in Wine. J Agri Food Chem. 50(3):431-35,2002. http://pubs.acs.org/journals/jafcau/