Flavanoids References 28414

April 3, 2006

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1. Galli RL et al. "Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection." Neurobiol Aging, 27, 2:344-50, 2006. http://www.sciencedirect.com/science/journal/01974580

2. Sweeney MI et al. Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage. Nutr Neurosci. 5(6):427-31, 2002.

3. Joseph JA et al. Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J Neurosci. 18, 19:8047-55, 1998. (http://www.jneurosci.org)

4. Meyers KJ et al. Antioxidant and antiproliferative activities of strawberries. J Agric Food Chem. 51(23):6887-92, 2003.

5. Casto BC et al. Chemoprevention of oral cancer by black raspberries. Anticancer Res. 22, 6C:4005-15, 2002. (http://www.iiar-anticancer.org/index2.htm)

6. Harris GK et al. Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer.40, 2:125-33, 2001. (http://www.leaonline.com/loi/nc)

7. Sun J et al. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem. 50, 25:7449-54, 2002. (http://pubs.acs.org/journals/jafcau)

8. McHarg T et al. Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation. BJU Int. 92, 7:765-8, 2003. (http://www.bjui.org)

9. Yamanaka A et al. Inhibitory effects of cranberry juice on attachment of oral streptococci and biofilm formation. Oral Microbiol Immunol. 19, 3:150-4, 2004. (http://www.blackwellpublishing.com/journal.asp?ref=0902-0055)

10. McHarg T et al. Influence of cranberry juice on the urinary risk factors for calcium oxalate kidney stone formation. BJU Int. 92, 7:765-8, 2003. (http://www.bjui.org)

11. Bagchi D et al. "Safety and whole-body antioxidant potential of a novel anthocyanin-rich formulation of edible berries." Mol Cell Biochem. 281,1-2:197-209, 2006.http://www.springerlink.com/link.asp?id=102965

12. Daniel RS et al. Mechanism of action of antiatherogenic and related effects of Ficus bengalensis Linn. flavonoids in experimental animals. Indian J Exp Biol. 41, 4:296-303, 2003. http://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb2k3/ijeb_apr03.htm

13. Bagchi D et al. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 69(1):75-80, 2004.

14. Roy S et al. Anti-angiogenic property of edible berries. Free Radic Res. 36(9):1023-31, 2002.

15. Chatterjee A et al. Inhibition of Helicobacter pylori in vitro by various berry extracts, with enhanced susceptibility to clarithromycin. Mol Cell Biochem. 265(1-2):19-26, 2004.

16. Auger C et al. Phenolics from commercialized grape extracts prevent early atherosclerotic lesions in hamsters by mechanisms other than antioxidant effect. J Agric Food Chem. 52(16):5297-302, 2004.

17. Bagchi D et al. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice.Gen Pharmacol. 30(5):771-6, 1998.

18. Deshane J et al. Proteomics analysis of rat brain protein modulations by grape seed extract. J Agri Food Chem. 52(26):7872-7883, 2004. http://pubs.acs.org/journals/jafcau/index.html19. ???

20. Kalin R et al. "Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis." Free Radic Res. 36, 8:819-25, 2002. http://taylorandfrancis.metapress.com

21. Tyson DA et al. "Acute effects of grape seed extract and niacin-bound chromium on cardiovascular parameters of normotensive and hypertensive rats." Res Comm Pharmacol Toxicol. 5, 1-2:91-106, 2000.

22. Neto CC et al. "MALDI-TOF MS characterization of proanthocyanidins from cranberry fruit (Vaccinium macrocarpon) that inhibit tumor cell growth and matrix metalloproteinase expression in vitro." <I>The Journal of the Science of Food and Agriculture<$>. 86, 1:18-25, 2006. http://www3.interscience.wiley.com.

23. Williamson G, Crespy V. A review of the health effects of green tea catechins in in vivo animal models. J Nutr. 134(12):3431S-3440S, 2004. www.nutrition.org

24. Chen D et al. "Green tea and tea polyphenols in cancer prevention." Front Biosci. 9:2618-31, 2004. www.bioscience.org

25. Dufresne CJ, Farnworth ER. A review of latest research findings on the health promotion properties of tea. J Nutr Biochem.12(7):404-421, 2001.

26. Sengupta A et al. Tea can protect against aberrant crypt foci formation during azoxymethane induced rat colon carcinogenesis. J Exp Clin Cancer Res. 22(2):185-91, 2003.

27. Singh AK et al. "Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo." Cancer Lett. 2006 [Epub ahead of print].http://www.sciencedirect.com/science/journal/03043835

28. Mukamal KJ et al. "Alcohol consumption and hemostatic factors: Analysis of the Framingham Offspring Cohort." Circulation. 104: 1367-73, 2001. http://circ.ahajournals.org

29. Negishi H et al. "Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats." J Nutr. 134(1):38-42, 2004. www.nutrition.org

30. Klaus S et al. "Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation." Int J Obes (Lond). 29, 6:615-23, 2005.

31a. Li R et al. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury.J Neurosci Res. 78(5):723-31, 2004.

31b. Mandel S et al. "Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases." J Neurochem. 88, 6:1555-69, 2004.

32. Alessio HM et al Consumption of green tea protects rats from exercise-induced oxidative stress in kidney and liver Nutr Res. 22, 10:1177-88, 2002. www.elsevier.com/locate/issn/02715317

33. Fiorini RN et al. Short-term administration of (-)-epigallocatechin gallate reduces hepatic steatosis and protects against warm hepatic ischemia/reperfusion injury in steatotic mice.  Liver Transpl. 11(3):298-308, 2005.

34. Tsuneki H et al. Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacol. 4(1):18, 2004.

35. Shoskes D et al. "Quercetin in men with category III chronic prostatitis: a preliminary prospective, double blind, placebo-controlled trial." Urology. 54, 6:960-963, 1999. http://www.goldjournal.net/

36. Schroeter H et al. "(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans." Proc Natl Acad Sci U S A. 103, 4:1024-9, 2006. www.pnas.org

37. Mathur S et al. "Cocoa products decrease low density lipoprotein oxidative susceptibility but do not affect biomarkers of inflammation in humans." J Nutr. 132, 12:3663-7, 2002.www.nutrition.org

38. Rein D et al. "Cocoa inhibits platelet activation and function." Am J Clin Nutr. 72, 1:30-5, 2000. www.ajcn.org

39. Buijsse B et al. "Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study." Arch Intern Med. 166, 4:411-7, 2006. http://archinte.ama-assn.org/

40. Innes AJ et al. "Dark chocolate inhibits platelet aggregation in healthy volunteers." Platelets. 14, 5:325-7, 2003.www.tandf.co.uk/journals/titles/09537104.asp

41. Schueir M et al. "Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia." J Nutr. 135, 10:2320-5, 2005. www.nutrition.org

42. Selga A and Torres JL. "Efficient Preparation of Catechin Thio Conjugates by One Step Extraction/Depolymerization of Pine (Pinus pinaster) Bark Procyanidins." J Agric Food Chem, 53, 20:7760-65, 2005. http://pubs.acs.org/journals/jafcau/index.html

43. Watson R. Reduction of cardiovascular disease risk factors by French maritime pine bark extract. Cardiovasc Rev Report. 6:326-329, 1999.

44. Huynh HT, Teel RW. Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol. Anticancer Res. 20(4):2417-20, 2000.

45. Liu X et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci. 75(21):2505-13, 2004.

46. Peng QL et al. Pycnogenol protects neurons from amyloid-beta peptide-induced apoptosis. Brain Res Mol Brain Res. 104(1):55-65, 2002.

47. Stefanescu M et al. Pycnogenol efficacy in the treatment of systemic lupus erythematosus patients. Phytother Res. 15(8):698-704, 2001.

48. Spadea L, Balestrazzi E. Treatment of vascular retinopathies with Pycnogenol. Phytother Res. 15(3):219-23, 2001.

49. Belcaro G et al. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost. 10(4):373-7, 2004.

50. Kohama T et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea: an open clinical trial. J Reprod Med. 49(10):828-32, 2004.

51. Liu FJ et al. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci. 54(10):1168-72, 1998.

52. Roseff SJ. Improvement in sperm quality and function with French maritime pine tree bark extract. J Reprod Med. 47(10):821-4, 2002.

53. Lau BH et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004

54. Roseff SJ et al. Oral administration of Pycnogenol affects baseline human sperm morphology, but not sperm count, motility or functions. Fertil Steril. 70(3):S265-66, 1998.

55. Lee CH et al. "Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits." Biochem Biophys Res Comm. 284, 3:681-8, 2001.www.sciencedirect.com/science/journal/0006291X

56. Ohtsuki K et al. Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats. J Nutr Sci Vitaminol(Tokyo). 48(5):420-2, 2002.

57. Barrett PH et al. Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry. 42(5):1283-91, 2003.

58. Whitman SC et al. "Nobiletin, a citrus flavonoid isolated from tangerines, selective inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages." Atherosclerosis. [in press 2005]www.elsevier.com/locate/atherosclerosis

59. Vinson JA et al. Polyphenol antioxidants in citrus juices: in vitro and in vivo studies relevant to heart disease. Adv Exp Med Biol. 505:113-22, 2002.

60. Kurowska EM, Manthey JA. "Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia."J Agric Food Chem. 52, 10:2879-86, 2004. http://pubs.acs.org/journals/jafcau

61. Wilmsen PK et al. "Antioxidant activity of the flavonoid hesperidin in chemical and biological systems." J Agric Food Chem, 53, 12:4757-61, 2005. http://pubs.acs.org/journals/jafcau/index.html

62. Heo HHJ et al. 'Effect of antioxidant flavanone, naringenin, from Citrus junoson neuroprotection." J Agric Food Chem. 52, 6:1520-5, 2004. http://pubs.acs.org/journals/jafcau/index.html

63. Keinin E et al. "Natural ozone scavenger prevents asthma in sensitized rats." Bioorg Med Chem. 13, 2:557-62, 2005. http://www.sciencedirect.com/science/journal/09680896

64. Ibid.

65. Delaney B et al. Immunotoxicity of a standardized citrus polymethoxylated flavone extract. Food Chem Toxicol. 39, 11:1087-94, 2001. http://www.sciencedirect.com/science/journal/02786915

66. Dias AS et al. "Quercetin Decreases Oxidative Stress, NF-B Activation, and iNOS Overexpression in Liver of Streptozotocin-Induced Diabetic Rats." J Nutr. 135, 10:2299-304, 2005. www.nutrition.org

67. Son YO et al. "Quercetin, a bioflavonoid, accelerates TNF-alpha-induced growth inhibition and apoptosis in MC3T3-E1 osteoblastic cells." Eur J Pharmacol, 529, 1-3:24-32, 2006. http://www.sciencedirect.com/science/journal/00142999

68. Zern TL et al. "Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress." J Nutr. 135, 8:1911-7, 2005. www.nutrition.org

69. O'Leary KA et al. "Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription." Mut Res. 551, 1-2:245-54, 2004.www.mutationresearch.com

70. Burnett B. A Combination Free-B-Ring Flavonoids and Flavan, Anti-Inflammatory Plant Extract Increases Memory and Speed of Processing in Animal and Human Clinical Models Presented at 12th Annual Conference on Polyphenols, Helsinki, Finland, August 2004.

71. Jenkins DJ et al. Effects of high- and low-isoflavone soyfoods on blood lipids, oxidized LDL, homocysteine, and blood pressure in hyperlipidemic men and women. Am J Clin Nutr. 76, 2:365-72. www.ajcn.org

72. Nestel P et al. A biochanin-enriched isoflavone from red clover lowers LDL cholesterol in men. Eur J Clin Nutr. 58, 3:403-8, 2004.www.nature.com/ejcn

73. Campbell MJ et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr. 58,1:173-9, 2004. www.nature.com/ejcn

74. Hedlund TE et al. Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in caucasian men. J Nutr. 135, 6:1400-6, 2005. www.nutrition.org

75. Kato K et al. Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. Japan J Cancer Res. 9, 8:786-91, 2000.www.jca.gr.jp

76. Hussain M et al. Soy isoflavones in the treatment of prostate cancer.Nutr Cancer. 47, 2:111-7, 2003.

77. Tahbaz F et al. "Assessment of soy phytoestrogens' effects on bone turnover indicators in menopausal women with osteopenia in Iran: a before and after clinical trial." Nutr J. 4:30, 2005. http://www.nutritionj.com/content/4/1/30

78. Watkins BA et al. Protective actions of soy isoflavones and n-3 PUFAs on bone mass in ovariectomized rats. J Nutr Biochem. 16, 8:479-88, 2005. http://www.sciencedirect.com/science/journal/09552863

79. Upmalis DH et al. "Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study." Menopause. 7, 4:236-42, 2000.www.menopausejournal.com

80. Dornstauder E et al. Estrogenic activity of two standardized red clover extracts Menoflavon intended for large scale use in hormone replacement therapy. J Steroid Biochem Mol Biol. 78, 1:67-75, 2001.www.sciencedirect.com/science/journal/09600760

81. Bryant M et al. Effect of consumption of soy isoflavones on behavioural, somatic and affective symptoms in women with premenstrual syndrome. Br J Nutr. 93, 5:731-9, 2005. http://www.ingentaconnect.com/content/cabi/bjn

82. Clavel T et al. "Isoflavones and Functional Foods Alter the Dominant Intestinal Microbiota in Postmenopausal Women." J Nutr, 135:2786-92, 2005. www.nutrition.org

83. De Boever P, et al. "Fermentation by gut microbiota cultured in a simulator of the human intestinal microbial ecosystem is improved by supplementing a soygerm powder." J Nutr. 130:2599-2606, 2000. www.nutrition.org

84. Tahbaz F et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food. 7(3):305-8, 2004.

85. Sumner MD et al. Effects of Pomegranate Juice Consumption on Myocardial Perfusion in Patients with Coronary Heart Disease. Amer J Cardiol. 96, 6:810-14, 2005. http://www.sciencedirect.com/science/journal/00029149

86. Yamasaki M. et al. "Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice." Nutrition, 22, 1:54-9, 2006. http://www.sciencedirect.com/science/journal/08999007

87. Malik A et al. "Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer." Proceedings of the National Academy of Sciences. 102, 41:14813-14818, 2005. www.pnas.org

88. Seeram NP et al. "In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice." J Nutr Biochem. 16, 6:360-7, 2005. www.elsevier.com/locate/jnutbio

89. Ludwig A et al. The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells.Biochem Biophys Res Commun. 316(3):659-665, 2004.

90. Anter E et al. Activation of eNOS by the p38 MAP kinase in response to black tea polyphenols. J Biol Chem. 279(45):46637-43, 2004.

91. Bucki R et al. Flavonoid inhibition of platelet procoagulant activity and phosphoinositide synthesis. J Thromb Haemost. 1(8):1820-1828, 2003.

92. Cho SY et al. Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Mol Cell Biochem. 243(1-2):153-160, 2003.

93. Kong AN et al. Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). Drug Metab Rev. 33(3-4):255-271, 2001.

94. Bagli E et al. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res. 64(21):7936-7946, 2004.

95. Wang W et al. Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines. Nutr Cancer. 48(1):106-114, 2004.

96. Sah JF et al. Epigallocatechin-3-gallate inhibits epidermal growth factor receptor signaling pathway. Evidence for direct inhibition of ERK1/2 and AKT kinases. J Biol Chem. 279(13):12755-12762, 2004.

97. Kavanagh KT et al. Green tea extracts decrease carcinogen-induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture. J Cell Biochem. 82(3):387-398, 2001.

98. Sakata K et al. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett. 199(2):139-145, 2003.

99. Simons AL et al. "Human Gut Microbial Degradation of Flavonoids: Structure-Function Relationships." J Agri Food Chem, 53, 10: 4258-4263, 2005. http://pubs.acs.org/journals/jafcau/index.html

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