Nutraceuticals for Brain Function

Cognitive dysfunction seems a natural effect of aging; however, it is being seen earlier in life, even as the prevalence of conditions such as Alzheimers disease (AD) are on the rise. In an article for Nutritional Outlook, Irfan Qureshi, N.D., vice president for technical and regulatory affairs for AIBMR Life Sciences, reviewed botanical and specialty ingredients with the potential to support cognitive health and stave off dementia through antioxidant, anti-inflammatory and circulatory effects.

Atop Qureshis list of key botanicals is turmeric (Curcuma longa); its active ingredient curcumin has been studied for its anti-inflammatory and antioxidant effects, affecting multiple pathways that influence brain health. Animal studies suggest turmeric and curcumin can prevent neural degeneration by increasing tolerance to stress; positively impact production of neurotransmitters; and improve brain insulin activity and acetylcholine levels.

Another herb with a rep for supporting the brain is sage (Salvia officinalis), which may improve cognitive function and memory. Other options in the botanical arena include Brahmi (Bacopa monnieri), used in Ayurvedic medicine for brain health and found in research to improve memory and cognition; resveratrol, which can improve cerebral blood flow and fight neural inflammation associated with cognitive dysfunction; and American ginseng (Panax quinquefolius), which has stress-reducing properties. Studies on a patent-pending American ginseng extract (as Cereboost, from Naturex) have shown its ability to improve memory performance.

Qureshi also called out several specialty ingredients for their ability to enhance brain health. Leading off the discussion is citicoline, specifically Cognizin, from Kyowa Hakko, which affects dopamine levels in the brain and could specifically help in appetite control. Another proprietary ingredient, lifesDHA, from Martek, was the subject of a study published in May 2010 that found algal docosahexaenoic acid (DHA) could improve memory and learning in older adults. And Chromax chromium picolinate, supplied by Nutrition 21, may also positively affect memory function in older adults, increasing brain activation.