PACran Relieves UTI Symptoms

CARVER, Mass.A proanthocyanidins-standardized whole-cranberry powder effectively reduced urinary tract infections (UTIs), according to a new study published in the journal Current Bioactive Compounds (2011 March;7(1):39-48). PACran from Decas Botanical Synergies LLC significantly reduced the presence of UTI symptoms in culture-positive subjects, whereas the untreated control group experienced no significant changes in symptoms.

In a 90-day clinical trial, 60 female subjects between 18 and 40 years of age were randomly selected and assigned to three groups including an untreated control group (N=16), a low dose (500 mg daily, N=21) and a high dose (1,000 mg daily, N=23) treatment group. Occurrence of UTI at baseline and during the follow-up period was characterized by the presence of symptoms and Escherichia coli (E. coli) in the culture of urine samples.

PACran significantly reduced the presence of E. coli (P=0.7234), but those who took the control saw no significant reductions. Both the high-dose and low-dose treatment groups experienced a reduction (P<0.05) of positive E. coli tests, compared to baseline evaluation. Symptomatic relief was also reported in the low- and high-dose treatment groups, while none was reported by subjects in the untreated control group.

The researchers concluded, Therefore, a daily dose of 500 mg or 1,000 mg of proanthocyanidins-standardized whole-cranberry powder may be considered as an adjunct to antibiotic prophylactic therapy against recurrent UTIs."

UTIs affect millions of people each year. Most infections arise from the bacteria E. coli and are the second most common type of infection in the body accounting for an estimated 11 million doctor visits and a U.S. health care cost of more than $1 billion each year.

PACran provides the most cost effective clinically supported dose of cranberry to the market. These published results, coupled with other human clinical studies conducted at Rutgers University have shown that a daily consumption of 500 mg of PACran helps support urinary tract health, " said Dan Souza, director of sales and marketing for Decas Botanical Synergies. DBS is committed to clinical substantiation of our products, and we will continue to set the bar in the market for cranberry nutraceuticals."