Raw Broccoli Improves Bladder Cancer Survival

BUFFALO, N.Y.Considering the strong preclinical evidence, intake of broccoli may improve bladder cancer survival, according to a study published in Cancer Epidemiology Biomarkers & Prevention (2010;19(7):180611). Cruciferous vegetables, such as broccoli, are a rich source of dietary isothiocyanates, and have been inversely associated with the risk of bladder cancer. And, due to its anti-proliferative effects it may also play a role in survival among patients with bladder cancer.

Using information obtained from the Roswell Park Cancer Institute Tumor Registry, patient medical records, and routinely collected questionnaire data, researchers examined potential associations between intake of cruciferous vegetables and survival among bladder cancer patients. Since cooking can substantially reduce or destroy isothiocyanates, consumption of raw versus cooked cruciferous vegetables was examined separately.

A total of 239 bladder cancer patients were included in the study. After an average of eight years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder cancer. After adjustment for other prognostic factors, a strong and significant inverse association was observed between bladder cancer mortality and broccoli intake, in particular raw broccoli intake. There were no significant associations for total vegetables, total fruits or other individual cruciferous vegetables.