Reducing Oxidative Stress in the Brain

NITRA, SlovakiaAntioxidants may help fight oxidative stress in the brain induced by high levels of certain metals, possibly reducing onset or progression of neurodegenerative conditions (Mol Cell Biochem. ePub 22 Aug 2010. DOI: 10.1007/s11010-010-0563-x). A review out of Constantine The Philosopher University, Nitra, Slovakia examined how increased oxidative stress in the brain, associated with greater brain content of iron and copper, could stimulate free radical formation, increase oxidative stress and decrease levels of endogenous antioxidants. Further, the advanced glycation end products (AGEs) seen in the situation can interact with other receptors that signal the formation of inflammatory cytokines. The team noted accumulation of ditryosine and 3-nitrotyrosine has been reported in subjects with Alzheimers disease, and may be associated with the development of amyloid- protein (A) and amyloid plaques. Further, development of Parkinsons disease has been shown to be linked to oxidative stress, as seen in the oxidative damage that degenerates dopaminergic neurons.

Therefore, the researchers looked at the possibility that individual antioxidants or combinations thereof could serve a neuroprotective purpose, decreasing the risk of conditions such as Alzheimers and Parkinsons. Among the beneficial antioxidants that may play a role are glutathione, vitamin C, vitamin E, lipoic acid, flavonoids and curcumin.