Stress, Inflammation & Depression

COLUMBUS, OhioThere is a key connection among diet, inflammation, stress and mood disorders, according to a review out of Ohio State University (Psychosom Med. 2010 May;72(4):365-9). Janice Kiecolt-Glaser, Ph.D., noted a variety of dietary compounds modulate many inflammatory pathways, a number of which are similarly affected by stress and depression. While the contributions of diet and behavior may add to inflammation, there are other connections. She noted stress influences food choices and can adversely impact metabolic response to unhealthy food choices. Also, activation of the vagus nerve adversely affects digestion and nutrient metabolism; depression and stress both have negative effects on vagal activation. One example cited by Kiecolt-Glaser was the fact that omega-3 fatty acids can boost mood and vagal tone, reduce production of inflammatory cytokines and decrease the bodys response to stress.