Niacin, Lovastatin May Lower LDL, Raise HDL

Niacin, Lovastatin May Lower LDL, Raise HDL

ANAHEIM, Calif.--Coupling a cholesterol-lowering drug with high-dose niacin may reducethe risk of heart disease, says one study. Research has found that large doses ofniacin--200 to 500 milligrams--can remedy cholesterol abnormalities in the blood whilesharply raising levels of HDL (the "good" cholesterol). However, this large dosemay leave users flushed, bring on a rash or cause liver damage. Nonetheless, combining anextended-release form of niacin with the cholesterol-lowering drug lovastatin dramaticallyimproved blood cholesterol levels without severe side effects, according to researchers atan American College of Cardiology meeting held here March 16.

This combination also raised HDL levels by 41 percent after one year in a trial of 814high-risk patients. "That's a very significant finding," said Adolph Hutter ofHarvard Medical School, who added that this combination represents an important option forpeople who need more help in curbing their cholesterol. For further information, callHutter at (617) 726-2884.