GliSODin Prevents Cognitive Impairment

Results from a recent study published in Behavioural Brain Research found GliSODin, a superoxide dismutase (SOD) supplement distributed by PL Thomas, prevented stress-induced impairment of cognitive function and maintained neurogenesis in the hippocampus through antioxidant activity (DOI:10.1016/j.bbr.2008.12.038).

Male C57BL/6 mice were divided into four groups: (1) control mice (C mice) fed in a normal cage without immobilization; (2) restraint-stressed (RS mice) fed in a small cage; (3) vitamin E mice (VE mice), mice were fed in a small cage with a diet supplemented with vitamin E; (4) GliSODin mice (GS mice) fed in a small cage with a diet supplemented with GliSODin. RS mice showed impaired spatial learning performance and an increased number of 4-HNE-positive cells in the granule cell layer (GCL) of the hippocampal dentate gyrus when compared to C mice. RS mice showed a decreased number of Ki67-positive cells in the subgranular zone (SGZ). GS mice showed better spatial learning memory than RS mice. The number of 4-HNE-positive cells in the GCL of GS mice was significantly less than that of RS mice. The number of Ki67-positive cells in the SGZ of GS mice was significantly greater than that of RS mice.