SGTIs CoQH-CF Shows Better Absorption Over CoQ10

LOS ANGELES—New research comparing the bioavailability of two coenzyme Q10 (CoQ10) formulations demonstrated CoQH-CF, the reduced CoQ10 formulation available from Soft Gel Technologies Inc. (SGTI), had superior absorption in its test subjects aged 60 and older. The study was published in the January 2009 issue of the Journal of Functional Foods.

The study compared the bioavailability of a single 100 mg dose of two CoQ10 formulations (CoQH-CF and CoQ10) in vivo. The results showed the AUC0-_t of reduced and total CoQ10 was statistically significantly higher in subjects who consumed CoQH-CF compared to those who ingested CoQ10, resulting in 4.3-fold higher plasma AUC0-_72h in the CoQH-CF group compared to those in the CoQ10 group. Plasma oxidized CoQ10 AUC0-_24h, AUC0-_48h and AUC0-_72h was statistically significantly higher in those taking CoQH-CF compared to those taking CoQ10, resulting in a 3.3-fold higher plasma AUC0-_72h.

Additionally, total CoQ10 reached maximum plasma concentrations 15.5 hours after supplementation with CoQH-CF compared to 26.5 hours after supplementation with CoQ10, suggesting a faster rate of absorption for the reduced form of CoQ10. The maximum plasma CoQ10 concentrations were statistically significantly higher for plasma oxidized CoQ10, reduced CoQ10 and total CoQ10 in subjects who took CoQH-CF compared to subjects who took CoQ10. Researchers concluded CoQH-CF was superior to CoQ10 for relative bioavailability.

“It’s like the old saying, ‘you are what you absorb,’” commented Steve Holtby, president and CEO of SGTI. “CoQ10 is a powerful, protective nutraceutical for heart and overall health, but if it is not absorbed and therefore utilized, it will not confer its true and potent benefits.”

CoQH-CF is Soft Gel Technologies’ proprietary enhanced delivery system for ubiquinol (reduced CoQ10). “CF” stands for “crystal-free,” as CoQ10 naturally is in a crystal/powder state. “We found that using food-grade d-limonene broke down the CoQ10 crystals without altering its chemical structure, and the idea behind smaller CoQ10 molecules is better absorption,” Holtby explained. “The biggest issue with CoQ10 products is absorption, so instead of focusing on the biological function of CoQ10, it’s almost more important to show better absorption. Now with this study demonstrating superior absorption in a cohort of aging individuals, our CoQH-CF offers the optimal, ultimate CoQ10 efficacy benefits shown in the years of efficacy research.”

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