Study: Bitter Orange Safe At Higher Dosage

WEST CALDWELL, N.J.A new study in Food and Chemistry Toxicology confirms bitter orange extract's safety in dosages up to 98 mg daily. The trial, A 60-Day Double-Blind, Placebo-Controlled Safety Study Involving Citrus aurantium (Bitter Orange) Extract" found no adverse effects in 60-day supplementation of bitter orange extract (as Advantra Z, from Nutratech Inc.).

The studythe longest trial to research bitter orange onlyfound no significant changes in blood pressure, blood chemistries or blood cell counts in both Advantra Z and placebo groups.

In June 2012, an FDA-funded study explored the safety of bitter orange extract, noting it shouldn't cause consumer harm at appropriate doses. Health Canada also released guidelines supporting use of up to 50 mg of p-synephrine daily; Intertek Cantox deemed dosages up to 60 mg were safe, but later increased it to between 70 mg and 100 mg.