Whitepaper Explains Capabilities, Limitations of Botanical DNA Tests

DNA testing of botanical products is in its infancy, which has led to confusion and misuse of test results, according to a whitepaper that questions the validity of tests used by the New York Attorney General’s recent investigation into botanical supplements.

Sandy Almendarez, VP of Content

March 11, 2015

4 Min Read
Whitepaper Explains Capabilities, Limitations of Botanical DNA Tests

DNA testing of botanical products is in its infancy, which has led to confusion and misuse of test results, according to a whitepaper that questions the validity of tests used by the New York Attorney General’s recent investigation into botanical supplements.

The whitepaper, “The Capabilities and Limitations of DNA Barcoding of Botanical Dietary Supplements," was commissioned by supplement industry trade associations, and written by four scientists with experience testing natural products.

 “Very little research has been conducted on the use of DNA barcoding for materials other than those that are fresh or living, especially on botanical extracts in dietary supplements where the DNA can be removed or degraded," the authors wrote. “Therefore, the use of DNA barcoding for finished dietary supplements is largely misunderstood and misapplied—even by those who claim to perform it. Despite several reports indicating the successful use of DNA barcode methods on botanical extracts, the results are erroneous and likely due to cross-contamination by raw or fresh materials either in manufacturing or in the laboratory conducting testing."

The whitepaper cites the recent investigation of botanicals conducted by the New York Attorney General Eric Schneiderman, and raises doubts on the conclusions reached by his office.

For instance, the authors wrote that DNA testing is not valid for botanical extract products because “Typically most, if not all, of the material containing cells (with the DNA) is removed during extraction, leaving the phytochemicals, but not the DNA," they wrote. The products tested in the Attorney General’s investigation are most likely made from extracts, industry has noted.

The whitepaper also pointed out:

  • Methods must be taken to ensure contamination of botanical samples does not occur,

  • Samples must be compared to a robust reference standard, and

  • Specialized training and experience in the field of plant species identification is required to obtain reliable results from botanical supplement testing.

However, the Attorney General has not released the data he used to question the products’ quality, despite industry’s call to do so. Thus, it is difficult to tell what measures the researchers took to ensure the tests were validated and samples weren’t adulterated.

“Numerous questions and concerns have been raised regarding the NY AG’s investigation, including the specific methods used and the experience of the scientists, and ultimately, the NY AG’s conclusions and actions based on the results," the authors wrote. “Without access to the complete methodology utilized, testing procedures and analytics employed, and the full test results, it is impossible to place any confidence in the announced outcomes of those tests. However, we can assert confidently that the conclusions—that a majority of supplements lacked any botanical at all—based only on the results of DNA barcoding tests were unjustified."

The white paper was commissioned by four trade associations representing the dietary supplement industry: the American Herbal Products Association (AHPA), the Consumer Healthcare Products Association (CHPA), the Council for Responsible Nutrition (CRN) and the United Natural Products Alliance (UNPA).

The authors of the whitepaper are Danica T. Harbaugh Reynaud, Ph.D., CEO, AuthenTechnologies LLC; Brent D. Mishler, Ph.D., director, University and Jepson Herbaria, University of California, Berkeley; James Neal-Kababick, director, Flora Research Labs LLC; and  Paula N. Brown, Ph.D., director, natural health and food products research group, British Columbia Institute of Technology.

Be sure to attend the panel discussion “Adulteration & Your Role in Delivering Value to Consumers: Quality, Safety & Efficacy" at Ingredient Marketplace on April 8 from 9 to 10:30 a.m. in Orlando. Speakers Steve Mister, president and CEO, CRN; Mark Blumenthal, founder and executive director, American Botanical Council (ABC);  and Dan Dwyer, managing partner, Kleinfeld, Kaplan and Becker LLP; will discuss brands’ role in ensuring a secure supply chain to  delivers products to consumers that are free of adulterants, meeting their promise of quality, safety and efficacy.

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About the Author

Sandy Almendarez

VP of Content, Informa

Summary

• Well-known subject matter expert within the health & nutrition industry with more than 15 years’ experience reporting on natural products.

• She cares a lot about how healthy products are made, where their ingredients are sourced and how they affect human health.

• She knows that it’s the people behind the businesses — their motivations, feelings and emotions — drive industry growth, so that’s where she looks for content opportunities.

Sandy Almendarez is VP of Content for SupplySide and an award-winning journalist. She oversees the editorial and content marketing teams for the B2B media brands SupplySide Supplement Journal and SupplySide Food & Beverage Journal, the education programming for the health and nutrition trade shows SupplySide Connect New Jersey and SupplySide West, the education program SupplySide Fresh for industry newcomers and community engagement across the SupplySide portfolio. She is a seasoned content strategist with a passion for health, good nutrition, sustainability and inclusion. With over 15 years of experience in the health and nutrition industry, Sandy brings a wealth of knowledge to her role as a content-focused business leader. With specialization in topics ranging from product development to content engagement, creative marketing and c-suite decision making, her work is known for its engaging style and its relevance for business leaders in the health and nutrition industry.

In her free time, Sandy loves running, drinking hot tea and watching her two kids grow up. She brews her own “Sandbucha” homemade kombucha; she’s happy to share if you’re ever in Phoenix!

Awards:

Speaker credentials

Resides in

  • Phoenix, AZ

Education

  • Arizona State University

Contact:

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