Study Documents DRcaps' Delayed Delivery

MORRISTOWN, N.J.Capsugel's 2013 scintigraphic in vivo study of its DRcaps capsules document the specially formulated acid-resistant hydroxypropyl methylcellulose (HPMC) capsules are an option for delayed delivery of acid-sensitive ingredients such as probiotics and enzymes.

Gamma scintigraphy is an established technique in which a radio label is swallowed and the disposition in the gut is photographed externally over time.

The results demonstrate the capsules' effective protection from early activation caused by stomach acids and complete release in intestines where products such as probiotics and enzymes work best. The capsules began to release 52 minutes after ingestion and completely released the ingredients in 72 minutes after ingestion.

"The results from this human clinical study provide scientific evidence of DRcaps capsules' acid-resistant and delayed-release performance to give confidence that DRCaps capsules are an excellent choice for delivery of acid-sensitive ingredients," said Dr. Keith Hutchison, senior vice president, research and development of Capsugel.

The study revealed that the capsules actually began releasing at 52 minutes when they were about to leave the stomach.

"That is 45 minutes later than an immediate release capsule and means that the contents of the capsules would often be released in the intestines where probiotics and enzyme ingredients are most effective," Dr. Hutchison said.

DRcaps capsules are designed with unique polymer properties to slow down capsule from opening immediately after swallowing without adding synthetic chemicals, solvents or other coating ingredients.

Dr. Hutchison added, "The special release properties built into the capsules provide acid-protection and delayed release."