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Thermo Fisher Scientific ~ Q Exactive Mass Spectrometer
June 1, 2011
2 Min Read
DENVERThermo Fisher Scientific introduced the Q Exactive Mass Spectrometer. It works by bringing together quadrupole precursor selection and high-resolution accurate mass (HR/AM) Orbitrap mass analysis in order to deliver high confidence quantitative and qualitative (quan/qual) workflows. Featuring HR/AM Quanfirmation capability, the Q Exactive mass spectrometer makes it possible to identify, quantify and confirm more trace-level metabolites, contaminants, peptides and proteins in complex mixtures in a single analytical run. High confidence results are obtained without sacrificing MS/MS sensitivity, mass resolution or quantitative reproducibility. Fast scanning and spectral multiplexing ensure the system is fully compatible with UHPLC separations. In addition, fast positive-negative scan-to-scan polarity switching enables detection of a wide range of compound types in a single analysis.
Ian Jardine, vice president of global R&D, Thermo Fisher Scientific purports that for laboratories performing protein identification, metabolism, forensic toxicology and food safety analyses, Quanfirmation makes it possible to perform time-saving, single-run quan/qual workflows routinely.
The updated design features of the product include:
Ion source optics increase sensitivity up to five-fold.
Integrated quadrupole mass filter enables precursor ion selection.
C-Trap ion optics and HCD collision cell offer fast HCD MS/MS scanning and improve low-mass ion transmission, thereby enhancing sensitivity and quantitative performance, particularly for experiments that use isobaric labeling.
Multiplexed detection increases overall system duty cycle for compatibility with UHPLC. Up to 10 precursor ions can be collected and stored prior to simultaneous detection in the Orbitrap.
Together these features make the Q Exactive system the ideal choice for unambiguous Quanfirmationthe identification, quantitation and confirmationof hundreds of trace-level components in complex matrices, in a single analytical run. And, the system supports time-saving workflows for emerging applications, such as food safety and forensic toxicology, which employ general extraction methodologies resulting in complex sample matrices for subsequent analysis by LC-MS. With the Q Exactive system, laboratories can identify proteins, metabolites and contaminants with greater confidence.
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