PhosphoLean Heightens Diet Success

WHITE BEAR LAKE, Minn.—An Italian study published in the July issue of the British Journal of Nutrition proves PhosphoLean™ NOPE + EGCG (from Chemi Nutra) can significantly improve a person’s ability to stay on their stressful diet and successfully lose weight. It has been shown that one-third of dieters drop off their diets in the crucial first few weeks, and as a result, they experience little if any success.
The study involving 138 overweight and obese men and women on an eight-week, low-calorie diet, showed the PhosphoLean group experienced only a 6-percent drop-out rate vs. a 27-percent drop-out rate for the placebo group. In addition, the treatment group improved insulin resistance, greater feelings of fullness, decreased depressive symptoms, and decreased binge eating feelings, all at statistically significant levels.
Scott Hagerman, president of Chemi Nutra, said, “A recently published meta-analysis of one to four year randomized controlled trials of several well-known diet compounds resulted in average weight reductions of less than 5 kg, even though the studies preselected subjects for their ability to adhere to the treatments. Due to the high stress of the hypo-caloric diets, both depression rates and attrition rates were very high, thus compromising the validity of the studies. In contrast, our PhosphoLean was proven to safely and effectively help dieters stay on their diets, and in addition, provided several other major physiological benefits. With the overweightness and obesity epidemics that threaten life expectancy and quality of life in the U.S., our PhosphoLean specialty ingredient will hopefully help many people to better manage their bodyweight and lead a healthier lifestyle.”
The mode of action for PhosphoLean is based on the active compound N-oleyl-ethanolamine (NOE), a newly discovered lipid mediator liberated from NOPE upon ingestion. NOE binds to a unique cell receptor class called peroxisome-proliferator-activated receptor-α (PPAR-α) found in the intestinal tract. These receptors, when activated, signal the brain center to decrease appetite and hence reduce food intake, leading to eventual loss of bodyweight. Currently there is a tremendous amount of research and development in this arena involving the manipulation of appetite via this intriguing cell-signaling mechanism.

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