Svetol® works as Thermogenic

GARDONNE, France—Green coffee bean extract (as Svetol®, from Berkem) has been demonstrated in company studies to inhibit the glucose-6-phosphatase—explaining its fat-burning action. Three concentrations were tested—157 mg, 315 mg and 472 mg of Svetol per liter of solution. After incubation of human liver microsomes with or without Svetol, researchers observed Svetol inhibits Glc-6-Pase (especially its T1 unit, at 315 mg/L and 472 mg/L). This was the first study where Svetol inhibited the T1 unit of the Glc-6-Pase in human microsomes; primarily linked to fat burning.

According to Sophie Lafay, Ph.D., scientific director at Berkem: “We demonstrated for the first time that Svetol is able to inhibit the Glc-6- Pase in a significant and competitive manner. The in vitro active doses are equivalent to the daily recommended dose of Svetol.”

Previous epidemiological studies demonstrated a link between high consumption of coffee (more than 6 to 7 cups/d) and reduced risk of developing type 2 diabetes. In vitro and in vivo complementary tests suggested chlorogenic acids (CGA) – especially 5-caffeoylquinic acid mainly found in green coffee beans – could regulate glucose metabolism.